Dr Kalpana Kumari Barhwal

Dr Kalpana Kumari Barhwal

Addl. Prof.
Physiology

physio_kalpana@aiimsbhubaneswar.edu.in

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Dr Kalpana Kumari Barhwal

Addl. Prof.

Physiology

Degree / Diploma Name of the University/ Institution Subject Year of Passing
PhD 2009 Physiology DIPAS, Delhi

  • Awarded with CSIR-UGC NET fellowship, 2005
  • Awarded with CSIR- Research Associateship, 2010
  • Awarded with DST-Fast Track Young Scientist scheme, 2013

  •  Awarded with International Brain Research Organization (IBRO) Travel award, Malaysia, 2007
  • Awarded with ‘Asia Pacific Society for Mountain Medicine (APSMM) for Best Paper award’, 2008, Delhi
  • Awarded with International Brain Research Organization (IBRO) Travel Award, Canberra, Australia, 2009
  • Awarded with International Brain Research Organization (IBRO) Travel Award, Vancouver, Canada, 2009
  • Awarded with ‘PGIBMS Best Oral presentation award’ during ‘Indian association of Biomedical Scientist (IABMS) conference, 2009, Chandigarh
  • Awarded with ‘CSIR- Research Associateship’, 2010
  • Awarded with ‘Dr. D.M. Kar Best Oral presentation award’ for during ‘Indian Academy of Neuroscience (IAN), 2011, Delhi

  • Indian Academy of Neuroscience (IAN) Life Member
  • Society of Neurochemistry of India (SNCI) Life Member
  • Indian Association of Biomedical Scientists (IABMS) Life Member
  • Asia Pacific Society for Mountain Medicine (APSMM) Life Member
  • International Brain Research Organization (IBRO) Life Member
  • Physiological Society of India (PSI) Life Member
  • Association of Physiologists and Pharmacologists of India Life Member

  • 1) Barhwal K, Singh SB, Hota SK, Jayalakshmi K, Ilavazhagan G.Acetyl-L-Carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. European Journal of Pharmacology: 2007 Sep 10;570(1-3):97-107. (Impact Factor: 2.7)
  • 2) Jayalakshmi K, Singh SB, Kalpana B, Sairam M, Muthuraju S, Ilavazhagan G. N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia. Physiology and Behavior: 2007 Nov 23;92(4):643-50. (Impact Factor: 2.8)
  • 3) Hota SK, Barhwal K, Singh SB, Ilavazhagan G.Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach. Neurochemistry International: 2007 Nov- Dec;51(6-7):384-90. (Impact Factor: 3.1)
  • 4) Hota SK, Barhwal K, Singh SB, Sairam M, Ilavazhagan G.NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia. Journal of Neuroscience Research: 2008 Apr;86(5):1142-52. (Impact Factor: 3.4)
  • 5) Hota SK, Barhwal K, Ray K, Singh SB, Ilavazhagan G.Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiology of Learning and Memory: 2008 May;89(4):522-32. (Impact Factor: 3.4)
  • 6)Hota SK, Barhwal K, Singh SB, Ilavazhagan G.Chronic hypobaric hypoxia induced apoptosis in CA1 region of hippocampus: a possible role of NMDAR mediated p75 NTR upregulation. Experimental Neurology: 2008 Jul;212(1):5-13. (Impact Factor: 4.6)
  • 7) Barhwal K, Hota SK, Prasad D, Singh SB, Ilavazhagan G.Hypoxia induced deactivation of NGF mediated ERK ½ signaling in hippocampal cell culture: neuroprotection with Acetyl-L-Carnitine. Journal of Neuroscience Research: 2008 Sep;86(12):2705-21. (Impact Factor: 3.4)
  • 8)Hota SK, Barhwal K,Baitharu I, Prasad D, Singh SB, Ilavazhagan G.Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment. Neurobiology of Disease: 2009 Apr;34(1):23- 39. (Impact Factor: 5.4) ISSN no 0969-9961
  • 9) Barhwal K, Hota SK, Baitharu I, Prasad D, Singh SB, Ilavazhagan G. Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: complementary roles of L-Type Calcium channel and NMDA receptors. Neurobiology of Disease: 2009 May; 34(2):230-44. (Impact Factor: 5.4)
  • 10) Barhwal K, Hota SK, Jain V, Prasad D, Singh SB, Ilavazhagan G.Acetyl-l-carnitine prevents hypobaric hypoxia–induced spatial memory impairment through extracellular related kinase–mediated nuclear factor erythroid 2-related factor 2 phosphorylation. Neuroscience: 2009 Mar 24 (161): 501-514. (Impact Factor: 3.3) ISSN No. 0306-4522
  • 11)Sunil Kumar Hota, Kalpana Barhwal Hota, Dipti Prasad, GovindasamyIlavazhagan, Shashi Bala Singh.Oxidative-stress-induced alterations in Sp factors mediate transcriptional regulation of the NR1 subunit in hippocampus during hypoxia. Free Radical Biology & Medicine: 2010 49: 178–191 (Impact Factor: 6.1)ISSN No: 0891-5849
  • 12) Kalpana Barhwal Hota, Sunil Kumar Hota, Om Prakash Chaurasia, Shashi Bala Singh. Acetyl-L-Carnitine mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2 regulated mitochondrial biosynthesis. Hippocampus: 2012 22(4):723-736(Impact Factor: 5.1) ISSN No. 1098-1063
  • 13) Kalpana B Hota, Sunil K Hota, Ravi B Srivastava, Shashi B Singh. Neuroglobin regulates hypoxic response of neuronal cells through Hif-1α and Nrf2 mediated mechanism. Journal of Cerebral Blood Flow and Metabolism: 2012 32(6):1046-1060 (Impact Factor: 5.0) ISSN No 0271-678X
  • 14)Jain V, Baitharu I, Barhwal K, Prasad D, Singh SB, Ilavazhagan G. Enriched environment prevents hypobaric hypoxia induced neurodegeneration and is independent of antioxidant signaling. Cellular and molecular Neurobiology: 2012 32(4):599-611 (Impact Factor: 2.1) ISSN No 0272-4340
  • 15) Baitharu I, Deep SN, Jain V, Barhwal K, Malhotra AS, Hota SK, Prasad D, Ilavazhagan G. Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat. Behavioral Brain Research: 2012, March 1;228(1):53-65. (Impact Factor: 3.4) ISSN No 0166-4328
  • 16) Sunil Kumar Hota, Kalpana Hota, Vijay Kumar Sharma, Saroj Das, Priyanka Dhar, BidhuBhusan Mahapatra, Ravi Bihari Srivastava, Shashi Bala Singh* Multi-Domain Cognitive Screening Test for neuropsychological assessment for cognitive decline in acclimatized low landers staying at high altitude. Indian Journal of Medical Research: 2012. Sep;136(3):411-420 (Impact factor: 1.8) ISSN No. 0971-5916
  • 17) IswarBaitharu, Vishal Jain, Satya Narayan Deep, Kalpana Barhwal Hota, Sunil Kumar Hota , Dipti Prasad, GovindasamyIlavazhagan. Withaniasomnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. Journal of Ethnopharmacology: 2012.Jan 30;145(2):431-441 (Impact Factor: 3.728)ISSN NO 0378-8741
  • 18)Dhar P, Sharma VK, Hota KB, Das SK, Hota SK, Srivastava RB, Singh SB. Autonomic cardiovascular responses in acclimatized lowlanders on prolonged stay at high altitude: a longitudinal follow up study. PLoS One. 2014 Jan 3;9(1)e84274. (Impact Factor: 3.73) ISSN No 1932-6203
  • 19) Sharma VK, Das SK, Dhar P, Hota KB, Mahapatra BB, Vashishtha V, Kumar A, Hota SK, Norboo T, Srivastava RB.Domain specific changes in cognition at high altitude and its correlation with hyperhomocysteinemia. PLoS One. 2014 Jul 2;9(7): (Impact Factor: 3.73)ISSN No 1932-6203
  • 20) Das SK, Barhwal K, Hota SK, Thakur MK, Srivastava RB. Disrupting monotony during social isolation stress prevents early development of anxiety and depression   like traits in male rats.BMC Neuroscience 2015 Feb 14;16:2. (Impact factor: 2.67) ISSN No 1471-2202
  • 21) Barhwal K, Das SK, Kumar A, Hota SK, Srivastava RB, Kumar B. Insulin Receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia.J Neurochemistry 2015 Oct;135(2):332-46 (Impact Factor: 4.5) ISSN No 1471-4159
  • 22) Das SK, Baitharu I, Barhwal K, Hota SK, Singh SK.Early mood behavioral changes following exposure to monotonous environment during isolation stress is associated with altered hippocampal synaptic plasticity in male rats. Neuroscience Letters, 2016 Jan; 612, 231-237 (Impact Factor: 2.1) ISSN No 0304-3940
  • 23) Kumar K, Sharma S, Vashistha V, Bharadwaj P, Kumar A, Barhwal K, Hota SK, Malairaman U, Singh B. Terminalia arjuna bark extract improves diuresis and attenuates acute hypobaric hypoxia induced cerebral vascular leakage. J Ethnopharmacology, 2016 Mar 2;180:43-53(Impact Factor: 3.0) ISSN No 0378-8741
  • 24) Biswal S, Sharma D, Kumar K, Nag TC, Barhwal K, Hota SK, Kumar B. Global hypoxia Induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiol Learn Mem. 2016 May 28 (Impact Factor: 3.6) ISSN No 1074-7427
  • 25) Vashishtha V, Barhwal K, Kumar A, Hota SK, Chaurasia OP, Kumar B. Effect of seabuckthorn seed oil in reducing cardiovascular risk factors: A longitudinal controlled trial on hypertensive subjects. Clin Nutr. 2017 Oct;36(5):1231-1238. (Impact Factor: 4.1) ISSN No 0261-5614
  • 26) Biswal S, Das D, Barhwal K, Kumar A, Nag TC, Thakur MK, Hota SK, Kumar B. Epigenetic Regulation of SNAP25 Prevents Progressive Glutamate Excitotoxicty in Hypoxic CA3 Neurons.  Mol Neurobiol. 2017 Oct;54(8):6133-6147 (Impact Factor: 6.1) ISSN No 0893-7648
  • 27) Kumar K, Sharma S, Kumar A, Bhardwaj P, Barhwal K, Hota SK. Acute and sub-acute toxicological evaluation of lyophilized Nymphaea x rubra Roxb. ex Andrews rhizome extract. RegulToxicolPharmacol. 2017 Aug;88:12-21. (Impact Factor: 2.0) ISSN No 0273-2300
  • 28) Sharma D, Biswal SN, Kumar K, Bhardwaj P, Barhwal KK, Kumar A, Hota SK, Chaurasia OP. Estrogen Receptor β Mediated Neuroprotective Efficacy of Cicermicrophyllum Seed Extract in Global Hypoxia. Neurochem Res. 2017 Dec;42(12):3474-3489 (Impact Factor: 2.1) ISSN No 0364-3190
  • 29) Vashishtha V, Barhwal KK, Malhotra VK, Kumar A, Hota SK, Norboo T, Chaurasia OP. Prevalence and risk factors of hypertension in acclimatized lowlanders staying at high altitude for different durations. J Hum Hypertens. 2018 May;32(5):359-366. (Impact Factor: 2.7) ISSN No 1476-5527
  • 30) Dhar P, Sharma VK, Das SK, Barhwal K, Hota SK, Singh SB. Differential responses of autonomic function in sea level residents, acclimatized lowlanders at >3500 m and Himalayan high altitude natives at >3500 m: A cross-sectional study. Respir PhysiolNeurobiol. 2018 Aug;254:40-48. (Impact Factor: 1.9) ISSN No  1569-9048
  • 31) Biswal S, Barhwal KK, Das D, Dhingra R, Dhingra N, Nag TC, Hota SK. Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia. Neurobiol Dis. 2018 Aug;116:39-52 (Impact Factor: 5.6) ISSN No 0969-9961
  • 32) Das SK, Dhar P, Sharma VK, Barhwal K, Hota SK, Norboo T, Singh SB.High altitude with monotonous environment has significant impact on mood and cognitive performance of acclimatized lowlanders: Possible role of altered serum BDNF and plasma homocysteine level. J Affect Disord. 2018 Sep;237:94-103 (Impact Factor: 3.5) ISSN No 0165-0327
  • 33)Das D, Biswal S, Barhwal KK, Chaurasia OP, Hota SK.Kaempferol Inhibits Extra-synaptic NMDAR-Mediated Downregulation of TRkβ in Rat Hippocampus During Hypoxia.Neuroscience. 2018 Nov 10;392:77-91.(Impact Factor: 3.3) ISSN No 0306-4522
  • 34) Sharma D, Barhwal KK, Biswal SN, Srivastava AK, Bhardwaj P, Kumar A, Chaurasia OP, Hota SK. Hypoxia-mediated alteration in cholesterol oxidation and raft dynamics regulates BDNF signalling and neurodegeneration in hippocampus. J Neurochem. 2019 Jan;148(2):238-251. doi: 10.1111/jnc.14609.
  • 35) Das D, Biswal S, Barhwal KK, Bhardwaj P, Kumar A, Hota SK, Chaurasia OP, Kumar B. Methanolic root extract of Codonopsis clematidea prevents hypoxia induced procoagulant state by inhibition of GPIb receptor regulated Lyn kinase activation. Phytomedicine. 2019 Jun;59: 152903. doi: 10.1016/j.phymed.2019.152903.
  • 36) Barhwal KK, Biswal S, Chandra Nag T, Chaurasia OP, Hota SK. Class switching of carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia. Free Radic Biol Med. 2020 Oct 6;161:102-114.
  • 37) Barhwal KK, Boppana S, Vashishtha V, Mahapatra SC. Conscious Abstinence from Smokeless Tobacco Evokes Higher Withdrawal Response and Impairs Cognitive Performance Independent of Sympathetic Response. Ann Neurosci. 2020 Jan;27(1):29-39.
Dr Kalpana Kumari Barhwal

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